Phosphatidylcholine is the main excipient in Curcumin Phytosome, which provides a medium for curcumin delivery in the formulation where curcumin is merely 20-25% by weight. This curcumin-phospholipid complex fails to inhibit the curcumin transformation and in reality only aids in absorption of the therapeutically inactive conjugates of curcumin and not the curcumin itself. The key to improving the therapeutic potential of curcumin is to inhibit its biotransformation into the inactive conjugates such as curcumin-glucuronides, the curcumin-phospholipids complex fails in this respect in addition to provide very little curcumin for the price paid by the consumers (500mg of formulation contains 20-25% of curcumin).
BioPerine® on other hand helps improving the bioavailability of the curcumin by inhibiting its transformation into inactive conjugates such as curcumin glucuronides and sulphates. C3 Complex contains 95% curcumin and its bioavailability in presence of 5mg of BioPerine® is enhanced by 20 folds delivering more active form of curcumin (and not the inactive conjugates) than any other so called bioavailable forms.
It is the reason why Curucmin C3 Complex is used in 95% of Research Trials including MD Anderson, UCLA etc. Phyisician Naturals Exclusively uses patented Curcumin C3 Complex in all its 12 curucmin products and formulated with BioPerine, Bromelain, Enteric Coating... Time Release etc., to significantly enhance its BioAvailability and absorption
There are many brands claiming 10-20-30 times absorption which is incorrect as the amount of active curcumin conjugates absorbed into the blood stream is significantly less which is never disclosed